Natural and synthetic compounds such as trimethoprim behave as inhibitors of efflux in Gram-negative bacteria
نویسندگان
چکیده
منابع مشابه
Multidrug efflux pumps of gram-negative bacteria.
Gram-negative bacteria tend to be more resistant to lipophilic and amphiphilic inhibitors than gram-positive bacteria. Such inhibitors include dyes, detergents, free fatty acids, antibiotics, and other chemotherapeutic agents. This property is used in the selective enrichment of gram-negative bacteria, especially of members of the family Enterobacteriaceae, for example with MacConkey agar (cont...
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We tested the effects of various putative efflux pump inhibitors on colistin resistance in multidrug-resistant Gram-negative bacteria. Addition of 10 mg/liter cyanide 3-chlorophenylhydrazone (CCCP) to the test medium could significantly decrease the MICs of colistin-resistant strains. Time-kill assays showed CCCP could reverse colistin resistance and inhibit the regrowth of the resistant subpop...
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Bacteria are able to sense an increase in cell population density and to respond to it by the induction of a particular set of genes. This mechanism, called quorum sensing, includes in gram-negative bacteria the production and secretion of an acyl homoserine lactone, which diffuses through the cell wall, from the cell to the medium. Bacteria use the quorum sensing mechanism to regulate a variet...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2010
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkq079